Table 7.

Additivity of FcRn protection in hematopoietic and radioresistant cells after IV administration: For all test compounds clearance in FcRn ko mice resembles the sum of clearance with full FcRn expression and the additional clearances from the lack of FcRn in hematopoietic and radioresistent endothelial/somatic cells.

			Average additional clearance (mL/day/kg)* from lack of FcRn in
Mouse model	Test compound	Average clearance in test system with full FcRn (mL/day/kg)	Hematopoietic cells*	Radioresistant cells*	Sum of clearance with full FcRn and additional clearances from lack of FcRn (mL/day/kg)	Average clearance in FcRn ko mice (mL/day/kg
hFcRn Tg32	mAb1	12.9	54.5	85.9	153	159
C57BL/6	anti-TNP mAb	14.6	51.9	45.5	112	100

^*estimated from differences of clearance in cohort 2 and cohort 3 vs. cohort 1.