Table 7.
Average additional clearance (mL/day/kg)* from lack of FcRn in | ||||||
---|---|---|---|---|---|---|
Mouse model | Test compound | Average clearance in test system with full FcRn (mL/day/kg) | Hematopoietic cells* | Radioresistant cells* | Sum of clearance with full FcRn and additional clearances from lack of FcRn (mL/day/kg) | Average clearance in FcRn ko mice (mL/day/kg |
hFcRn Tg32 | mAb1 | 12.9 | 54.5 | 85.9 | 153 | 159 |
C57BL/6 | anti-TNP mAb | 14.6 | 51.9 | 45.5 | 112 | 100 |
estimated from differences of clearance in cohort 2 and cohort 3 vs. cohort 1.