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. 2018 Jun 15;10(28):23529–23538. doi: 10.1021/acsami.8b04557

Figure 4.

Figure 4

(a) Colloidal stability of nanoparticles in PBS. (b) Biodegradation tests of the BPSi and DPEG-BPSi nanoparticles in PBS with pH 7.4 at 37 °C for different time periods. The DPEG-BPSi nanoparticles were heated with the laser for 10 min before the biodegradation tests to study the effect of laser heating. (c) Fluorescent confocal microscope image on the uptake of BPSi and DPEG-BPSi nanoparticles into CT 26 cells after the incubation of 10 min and 1.0 h. (d) Viability of the CT 26 cells after photothermal treatments with different concentrations of DPEG-BPSi nanoparticles. The number of the samples per group was four. (e) The relative number of live, apoptotic, late apoptotic, and necrotic CT 26 cells after a 10 min laser heating of the medium with 75 μg/mL DPEG-BPSi nanoparticles followed by 12 h of incubation in nanoparticle-free media. The control (Contr) and laser (Laser) samples do not contain nanoparticles. Statistical analysis was done by one-way ANOVA: P < 0.0001 (****), as compared with the control group.