TABLE 2.
Associations between three indices of periodontal disease case status and prevalent systemic conditions in dental ARIC study
| Cases/Totals Case Status (N) |
Diabetes 921/6,672 OR (95% CI)a |
CHDb 355/6,486 OR (95% CI)a |
Strokeb 87/6,218 OR (95% CI)a |
CRP 1,378/5,510 OR (95% CI)a |
IL-6 1,352/5,439 OR (95% CI)a |
|---|---|---|---|---|---|
| PPC-Health (1,845) | Ref | Ref | Ref | Ref | Ref |
| PPC-Mild (1,047) | 1.21 (0.93-1.58) | 1.22 (0.82-1.83) | 1.50 (0.69-3.26) | 1.20 (0.97-1.49) | 1.25 (1.01-1.55) |
| PPC-High GI (694) | 1.61 (1.18-2.18) | 1.87 (1.16-3.04) | 0.92 (0.34-2.53) | 1.36 (1.02-1.82) | 1.39 (1.05-1.85) |
| PPC-Tooth Loss (800) | 1.44 (1.09-1.89) | 1.61 (1.07-2.41) | 1.04 (0.43-2.52) | 1.54 (1.22-1.94) | 1.50 (1.19-1.89) |
| PPC-Posterior Disease (999) | 1.16 (0.89-1.53) | 1.32(0.88-1.97) | 0.73 (0.29-1.86) | 1.18 (0.95-1.47) | 1.29 (1.01-1.61) |
| PPC-Severe Tooth Loss (900) | 1.59 (1.21-2.08) | 1.76 (1.17-2.65) | 2.08 (0.98-4.43) | 1.39 (1.10-1.76) | 1.28 (1.01-1.62) |
| PPC-Severe Disease (508) | 1.88 (1.38-2.56) | 1.56 (0.96-2.54) | 2.39 (1.01-5.64) | 1.50 (1.11-2.02) | 1.52 (1.15-2.03) |
| Total (6,793) | |||||
| BIC Improvementc | 20.57 | 10.60 | 12.04 | 16.75 | 15.31 |
| CDC-Health (775) | Ref | Ref | Ref | Ref | Ref |
| CDC-Mild (2,035) | 0.82 (0.63-1.07) | 1.04 (0.66-1.64) | 0.72 (0.33-1.56) | 1.00 (0.80-1.24) | 1.15 (0.92-1.45) |
| CDC-Moderate (2,799) | 1.19 (0.92-1.53) | 1.11 (0.73-1.71) | 0.87 (0.42-1.80) | 0.95 (0.77-1.18) | 1.22 (0.97-1.53) |
| CDC-Severe (1,184) | 1.21 (0.91-1.61) | 1.55 (0.98-2.44) | 0.99 (0.44-2.22) | 1.08 (0.84-1.38) | 1.25 (0.97-1.62) |
| Total (6,793) | |||||
| BIC Improvement‡ | 17.70 | 7.41 | 1.15 | 1.69 | 3.60 |
| European-Health (749) | Ref | Ref | Ref | Ref | Ref |
| European-Incipient (5,021) | 1.07 (0.84-1.36) | 1.12 (0.74-1.70) | 0.79 (0.40-1.58) | 0.98 (0.80-1.19) | 1.08 (0.88-1.34) |
| European-Severe (973) | 1.20 (0.89-1.61) | 1.97 (1.23-3.14) | 1.23 (0.55-2.76) | 1.11 (0.85-1.44) | 1.38 (1.06-1.79) |
| Total (6,793) | |||||
| BIC Improvementc | 1.61 | 16.82 | 2.57 | 1.68 | 7.47 |
Odds ratios adjusted as follows: logistic regression model for Diabetes adjusted for race, age, gender, body mass index (BMI), smoking (three levels) and education (three levels); logistic regression models for Heart Attack and Stroke adjusted for race, age, gender, BMI, smoking (three levels), diabetes, hypertension, education (three levels), high-density lipoprotein, low-density lipoprotein, triglycerides, and total cholesterol; logistic regression models for C-reactive protein (CRP) and interleukin (IL)-6 adjusted for race, age, gender, BMI, smoking (three levels), diabetes, hypertension, and education (three levels). Bolded text identifies statistically significant odds ratios.
CHD excludes Stroke cases; Stroke excludes CHD cases
NHANES, National Health and Nutrition Examination Survey; CHD, coronary heart disease; GI, gingival inflammation.
Bayesian Information Criterion (BIC)
BIC Improvement Evidence for Higher BIC
0 to 2 Not worth more than a bare mention
2 to 6 Positive
6 to 10 Strong
≤ 10 Very Strong