. Author manuscript; available in PMC: 2019 Sep 1.

Published in final edited form as: Neurogastroenterol Motil. 2018 May 10;30(9):e13370. doi: 10.1111/nmo.13370

Table 1.

Main properties of cannabinoid receptor agonists and antagonists. Reproduced with permission from ref. 25, Curr Gastroenterol Rep 2015;17:429.

AGONISTS
Plant Derived
Δ⁹-THC	Main psychoactive cannabinoid in the marijuana plant
Δ⁸-THC	Slightly less potent than Δ⁹-THC
11-OH-Δ⁹-THC	Bioactive compound formed when the body breaks down Δ⁹-THC
Animal Derived
Anandamide	2-AG
THC Analogs
Dronabinol	Nabilone, CP-55,940, HU-210, levonantradol
Different Chemical Structure
WIN-55,212	Binds to both cannabinoid receptors
ANTAGONISTS
SR-241716A	Synthetic CB1 antagonist
SR-144528	Synthetic CB2 antagonist
AM841	CB1 mega-agonist with negligible central effects at doses that potently reduce GI motor function
WIN-55,212-2	A weaker CB1R/CB2R non-selective cannabinoid agonist