Table 4.
Hazard Ratios and 95% Confidence Intervals for Incident Atrial Fibrillation According to Methylenetetrahydrofolate Reductase Mutation Presence, Stratified by Race (3052 African Americans and 9634 whites), ARIC, 1987–2013.
| Methylenetetrahydrofolate reductase risk alleles
|
||||
|---|---|---|---|---|
| African American | GG | GA | AA | p for trend |
| Number at risk | 2386 | 621 | 45 | |
| Person-years | 49,617 | 13,006 | 978 | |
| Atrial fibrillation, cases | 271 | 74 | 9 | |
| Model 1 | 1 | 1.04 (0.80–1.35) | 1.70 (0.88–3.31) | 0.311 |
| Model 2 | 1 | 1.07 (0.82–1.38) | 1.72 (0.88–3.37) | 0.240 |
|
| ||||
| Methylenetetrahydrofolate reductase risk alleles
|
||||
| White | GG | GA | AA | p for trend |
|
| ||||
| Number at risk | 4314 | 4212 | 1108 | |
| Person-years | 92,172 | 89,302 | 23,304 | |
| Atrial fibrillation, cases | 783 | 756 | 186 | |
| Model 1 | 1 | 1.00 (0.90–1.10) | 0.99 (0.85–1.11) | 0.621 |
| Model 2 | 1 | 1.02 (0.92–1.13) | 0.93 (0.79–1.09) | 0.612 |
Model 1: Crude model.
Model 2: Adjusted for age, sex and principal components of ancestry.