Table 5.

Hazard Ratios and 95% Confidence Intervals for Incident Atrial Fibrillation According to Plasma B Vitamins Levels among the Cohort Random Sample (n=492), ARIC, 1987–2013.

		Quartiles of plasma vitamin B6 concentration (median, range pmol/L)
	Log2(vitamin B6)	14.3 (0.1–20.2)	25.7 (20.3–34.0)	43.0 (34.1–59.7)	89.4 (60.4–480.0)
Person-years	10,106	2343	2419	2829	2515
Cases	85	23	22	17	23
Model 1	0.89 (0.77–1.03)	1	0.69 (0.31–1.54)	0.64 (0.27–1.50)	0.53 (0.24–1.21)
Model 2	0.88 (0.74–1.05)	1	0.72 (0.33–1.58)	0.70 (0.23– 2.14)	0.49 (0.20–1.20)
Model 3	0.91 (0.77–1.09)	1	1.05 (0.45–2.44)	0.81 (0.32–2.03)	0.49 (0.17–1.38)
		Quartiles of plasma vitamin B12 concentration (median, range pmol/L)
	Log2(vitamin B12)	162.0 (40.0–200.0)	235.0 (201.0–280.0)	323 (281.0–367.0)	449 (368.0–1217.0)
Person-years	10,106	2562	2515	2493	2535
Cases	88	25	28	14	18
Model 1	0.70 (0.46–1.07)	1	0.84 (0.37–1.88)	0.60 (0.25–1.47)	0.55 (0.24–1.28)
Model 2	0.77 (0.50–1.17)	1	0.89 (0.37–2.12)	0.59 (0.24–1.47)	0.58 (0.25–1.33)
Model 3	0.75 (0.42–1.34)	1	0.55 (0.22–1.39)	0.52 (0.20–1.37)	0.70 (0.28–1.76)
		Quartiles of plasma folate concentration (median, range pmol/L)
	Log2(folate)	1.4 (0.3–3.2)	5.3 (3.3–7.1)	9.3 (7.2–12.9)	18.4 (13.2–60.1)
Person-years	10,106	2590	2402	2563	2551
Cases	88	23	26	21	15
Model 1	0.85 (0.69–1.06)	1	0.65 (0.28–1.48)	0.69 (0.29–1.67)	0.43 (0.19–0.99)
Model 2	0.89 (0.72–1.11)	1	0.85 (0.33–2.16)	0.97 (0.39–2.43)	0.45 (0.19–1.09)
Model 3	0.90 (0.69–1.18)	1	1.03 (0.34–3.14)	1.45 (0.55–3.85)	0.41 (0.12–1.43)

Model 1: Adjusted for age, sex, race, field center.

Model 2: Adjusted for Model 1 + body mass index, height, systolic and diastolic blood pressure, anti-hypertension medication, diabetes mellitus, smoking status, drinking status, and, left ventricular hypertrophy.

Model 3: Adjusted for Model 2 + time-varying coronary heart disease and heart failure.