Table 2.

Multilevel Models of Orbital Frontal Cortex (OFC) Volume Residuals, OFC Surface Area, and OFC Thickness by Time-Varying CDI-C Anhedonia T-Score (N=193)

DV: OFC Volume Residuals	Estimate	SE	t	p
Intercept	−0.1131	0.1868	−0.61	0.5457
Age at scan	−0.1228	0.0261	−4.71	<0.0001
Age at scan squared	−0.0337	0.0106	−3.19	0.0017
Male gender	0.1328	0.2575	0.52	0.6066
MDD core score without anhedonia	−0.0352	0.0256	−1.38	0.1702
CDI-C anhedonia T-score	0.0029	0.0060	0.48	0.6291
MDD core score without anhedonia X Age at scan	−0.0148	0.0141	−1.04	0.2972
CDI-C anhedonia T-score X Age at scan	−0.0102	0.0033	−3.06	0.0025
DV: OFC Surface Area (mm2)	Estimate	SE	t	p
Intercept	9691.18	3301.10	2.94	0.0035
Age at scan	−27.3667	141.31	−0.19	0.8465
Male gender	499.29	306.37	1.63	0.1054
MDD core score without anhedonia	−20.1196	3.7569	−5.36	<0.0001
CDI-C anhedonia T-score	0.6699	0.9033	0.74	0.4594
MDD core score without anhedonia X Age at scan	0.8103	2.3846	0.34	0.7344
CDI-C anhedonia T-score X Age at scan	−0.4704	0.6023	−0.78	0.4356
DV: OFC Thickness (mm)	Estimate	SE	t	p
Intercept	10.8609	0.0429	253.12	<0.0001
Age at scan	−0.1555	0.0082	−18.97	<0.0001
Age at scan squared	−0.0134	0.0034	−3.90	0.0001
Male gender	0.0824	0.0584	1.41	0.1600
MDD core score without anhedonia	−0.0070	0.0087	−0.80	0.4235
CDI-C anhedonia T-score	0.0016	0.0020	0.79	0.4328
MDD core score without anhedonia X Age at scan	−0.0064	0.0047	−1.37	0.1717
CDI-C anhedonia T-score X Age at scan	−0.0032	0.0011	−2.96	0.0036