Table 1.
ART and childhood cancer publications discussed in the present editorial
| Children born | Standardized incidence ratio/odds ratio | ||
|---|---|---|---|
| Wainstock T, et al. Am J Obstet Gynecol (2017) | Singleton | 2603 ART children born | 1.89 (95% CI 0.89–4.02) |
| Infants born population cohort analysis 1991–2013 | 1721 ovulation induction | 2.03 (95% CI 0.96–4.30) | |
| Raimondi S, et al. British Journal of Cancer (2005) | Meta-analysis up to 2005 | 38,815 ART children | 1.33 (95% CI 0.62–2.85) 11 studies |
| 11 studies—8 excluding three studies with different designs | 0.77 (95% CI 0.41–1.42) 8 studies | ||
| Reigstad MM, et al. Pediatrics (2016) | Medical Birth Registry of Norway 1984–2011 | 25,782 ART children born | 1.21 (95% CI 0.90–1.63) |
| Hargreave M, et al. Fertil Steril (2013) | Meta-analysis up to 2011 | / | 1.33 (96% CI 1.08–1.63) |
| 10 studies | |||
| Hargreave M, et al. Int J Cancer (2013) | Danish Infertility Cohort Infertile women 1999–2009 | 125,844 children born after maternal infertility evaluation | 1.18 (95% CI, 1.05–1.32) |
| Hargreave M, et al. Int J Cancer (2015) | Danish Cancer Registry women 1963–2009 | 90,888 children born after maternal infertility evaluation | 1.18 (95% CI, 1.05–1.32) |
| Williams CL, et al. N Engl J Med (2013) | UK National Registry of Childhood Tumours 1992–2008 | 106,013 children born after ART no donor | 0.98 (95% CI 0.81–1.19) |
| Williams CL, et al. Hum Reprod (2018) | Retrospective cohort study 1992–2008 | 12,137 children born after donor ART | 0.83 (95% CI 0.43–1.45) |