Table 2.
Pathways enrichment analysis of pQTLs for LTB4 production in asthmatic LCLs
| Pathway rank | Pathway name | Gene symbol | SNP ID | Adjusted pathway P value |
|---|---|---|---|---|
| 1 | Fc gamma R-mediated phagocytosis | PRKCE | rs2176347 | 1.41E-05 |
| PRKCE | rs1878384 | |||
| VAV1 | rs347033 | |||
| VAV3 | rs6680436 | |||
| WASF3 | rs9512311 | |||
| PIK3R5 | rs516434 | |||
| PIK3R1 | rs3730082 | |||
| PIK3R1 | rs16897561 | |||
| PRKCD | rs17052826 | |||
| DOCK2 | rs2161148 | |||
| SYK | rs12550873 | |||
| SYK | rs290212 | |||
| SYK | rs4744505 | |||
| SYK | rs1333630 | |||
| 2 | Fc epsilon RI signaling pathway | PRKCE | rs2176347 | 2.26E-05 |
| PRKCE | rs1878384 | |||
| VAV1 | rs347033 | |||
| VAV3 | rs6680436 | |||
| PIK3R5 | rs516434 | |||
| PIK3R1 | rs3730082 | |||
| PIK3R1 | rs16897561 | |||
| PRKCD | rs17052826 | |||
| MAPK14 | rs2237093 | |||
| SYK | rs12550873 | |||
| SYK | rs290212 | |||
| SYK | rs4744505 | |||
| SYK | rs1333630 | |||
| 3 | Focal adhesion | VAV1 | rs347033 | 5.52E-05 |
| VAV3 | rs6680436 | |||
| PIK3R5 | rs516434 | |||
| ITGA6 | rs7584977 | |||
| ITGA6 | rs7596259 | |||
| PIK3R1 | rs3730082 | |||
| PIK3R1 | rs16897561 | |||
| RELN | rs362732 | |||
| COL4A1 | rs631428 | |||
| ACTN1 | rs2300875 | |||
| ITGAV | rs3738919 | |||
| EGFR | rs13244925 | |||
| SHC2 | rs740871 | |||
| 4 | Adherens junction | WASF3 | rs9512311 | 8.58E-05 |
| ACTN1 | rs2300875 | |||
| PTPRB | rs2717418 | |||
| PTPRM | rs2005039 | |||
| EGFR | rs13244925 | |||
| TCF7L2 | rs3814573 | |||
| CTNNA2 | rs383452 | |||
| CTNNA2 | rs1816909 | |||
| 5 | Endometrial cancer | PIK3R5 | rs516434 | 0.0001 |
| EGFR | rs13244925 | |||
| TCF7L2 | rs3814573 | |||
| PIK3R1 | rs3730082 | |||
| PIK3R1 | rs16897561 | |||
| CTNNA2 | rs383452 | |||
| CTNNA2 | rs1816909 | |||
| AXIN2 | rs4541111 | |||
| 6 | Neurotrophin signaling pathway | MAP2K5 | rs3784716 | 0.0003 |
| PIK3R5 | rs516434 | |||
| PIK3R1 | rs3730082 | |||
| PIK3R1 | rs16897561 | |||
| PRKCD | rs17052826 | |||
| NTRK3 | rs2279409 | |||
| NTRK3 | rs3784410 | |||
| MAPK14 | rs2237093 | |||
| NTRK2 | rs4486281 | |||
| SHC2 | rs740871 | |||
| 7 | Regulation of actin cytoskeleton | VAV1 | rs347033 | 0.0003 |
| VAV3 | rs6680436 | |||
| PIK3R5 | rs516434 | |||
| ITGA6 | rs7584977 | |||
| ITGA6 | rs7596259 | |||
| FGF18 | rs4620037 | |||
| PIK3R1 | rs3730082 | |||
| PIK3R1 | rs16897561 | |||
| ACTN1 | rs2300875 | |||
| ITGAV | rs3738919 | |||
| F2R | rs153311 | |||
| EGFR | rs13244925 | |||
| 8 | Pathways in cancer | GLI3 | rs2299142 | 0.0004 |
| GLI3 | rs846266 | |||
| GLI3 | rs846335 | |||
| PIK3R5 | rs516434 | |||
| ITGA6 | rs7584977 | |||
| ITGA6 | rs7596259 | |||
| FGF18 | rs4620037 | |||
| PIK3R1 | rs3730082 | |||
| PIK3R1 | rs16897561 | |||
| AXIN2 | rs4541111 | |||
| COL4A1 | rs631428 | |||
| ITGAV | rs3738919 | |||
| ETS1 | rs7115613 | |||
| ETS1 | rs4628683 | |||
| EGFR | rs13244925 | |||
| TCF7L2 | rs3814573 | |||
| CTNNA2 | rs383452 | |||
| CTNNA2 | rs1816909 | |||
| 9 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ACTN1 | rs2300875 | 0.0005 |
| ITGAV | rs3738919 | |||
| CACNB2 | rs1571787 | |||
| ITGA6 | rs7584977 | |||
| ITGA6 | rs7596259 | |||
| TCF7L2 | rs3814573 | |||
| CTNNA2 | rs383452 | |||
| CTNNA2 | rs1816909 | |||
| 10 | Type II Diabetes mellitus | PRKCE | rs2176347 | 0.0006 |
| PRKCE | rs1878384 | |||
| PIK3R5 | rs516434 | |||
| CACNA1E | rs1999838 | |||
| PIK3R1 | rs3730082 | |||
| PIK3R1 | rs16897561 | |||
| PRKCD | rs17052826 |