Fig. 1.

Comparison of TrkB/TrkA and TrkC/TrkA double positive sensory neurons in human and mouse dorsal root ganglia (DRG). (A, B, E, F) Representative dual-color fluorescence in situ hybridizations using probes to detect TrkA (red) and TrkB (green; A, B) or TrkA (red) and TrkC (green; E, F) were performed using human (A, E) or mouse (B, F) DRG tissue sections. Inserts show a close-up of labeled neurons with arrowheads in (E) and (F) indicating double-positive cells. (C, G) Quantifications of neurons double-positive for TrkA and TrkB (C) or TrkA and TrkC (G) are represented as scatter blots (mean ± SEM is shown). No significant (ns) difference was found when comparing tissues of both species (linear mixed model; p (TrkB) = 0.956; p (TrkC) = 0.111). Differently oriented or shaded triangles indicate percentages found in DRG sections obtained from different human individuals (N = 3), differently oriented or shaded squares depict percentages found in sections obtained from different mice (N = 3); (D, H) Venn diagrams depicting the percentage of TrkB/TrkA (D) or TrkC/TrkA (H) double positive cells from all TrkA expressing cells, in human and mouse tissue. Scale bar = 100 μm.