Fig. 3.

A higher percentage of TRPV1/TRKA1 positive neurons reside in human compared to mouse DRGs. (A, B) Dual-color fluorescence in situ hybridizations using probes to detect TrkA (red) and Trpv1 (green) in human (A) and mouse (B) DRG sections are shown. Inserts display close-ups with arrowheads indicating double-positive neurons. (C) Quantification of double-positive neurons in human (h) versus mouse (m) DRGs (expressed as percentage Trpv1 positive cells of all TrkA positive cells), showed a significant difference between the two species (linear effects model; data shown as mean ± SEM; p = 0.0003 ***). Differently oriented or shaded triangles indicate percentages found in DRG sections obtained from different human individuals (N = 3), differently oriented or shaded squares depict percentages found in sections obtained from different mice (N = 4); scale bar = 100 μm. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)