Fig. 1.

Cisplatin treatment results in a delayed mechanical and thermal hypersensitivity. [A] P7 rats were treated with either i.p. injections of vehicle or cisplatin (1 mg/kg) for 5 consecutive days. [B] Experimental groups of animals did not display any alterations in mechanical withdrawal threshold between P6 and P20. However, from P22 to the end of the experiment the cisplatin-treated animals displayed a reduction in withdrawal threshold to mechanical stimulation when compared to vehicle injection (^*P < 0.05, ^***P < 0.001 Two ANOVA with post Bonferroni test; vehicle = 7, cisplatin n = 5). [C] In response to heat, animals from both experimental groups demonstrated similar withdrawal latencies. At P22 cisplatin-treated animals displayed a reduction in withdrawal latency to heat stimulation (^**P < 0.01, ^***P < 0.001 Two ANOVA with post Bonferroni test; vehicle = 7, cisplatin n = 5).