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Timelines of pneumothorax recurrence in five patients with lymphangioleiomyomatosis (LAM) who were treated with sirolimus. All five patients had recurrent pneumothoraces before sirolimus treatment. The pneumothorax was induced by pregnancy in case 1. During sirolimus treatment, no patient developed pneumothorax. However, when the patients discontinued sirolimus or exhibited an undetectable trough level due to interaction with anti-tuberculosis drugs, the pneumothorax relapsed
