Table 3.
pMSCs modulate expression of genes mediating endothelial cell (EC) angiogenesis
| Number | Gene symbol | Gene full name | Glucose ΔΔ−2 value | Glucose + CMpMSC ΔΔ− 2 value | Fold change, glucose vs glucose + CMpMSC (p < 0.05) | Biological activity |
|---|---|---|---|---|---|---|
| 1 | AGT | Angiotensinogen | 3.3 | 0.004 | 825-fold ↓ | Inhibits EC angiogenesis |
| 2 | COL18A1 | Collagen, type XVIII, alpha 1 | 463 | 4 | 115-fold ↓ | |
| 3 | F2R | Protease-activated receptor-1 | 1.8 | 104.45 | 58.02-fold ↑ | Induces EC angiogenesis |
| 4 | ICAM1 | Intercellular adhesion molecule 1 | 11.5 | 23.85 | 2.07-fold ↑ | |
| 5 | PGF | Placental growth factor | 3.21 | 22.27 | 6.93-fold ↑ | |
| 6 | CCL2 | Monocyte chemotactic protein-1 (MCP-1) | 17.72 | 35.67 | 2.01-fold ↑ | |
| 7 | EDN1 | Endothelin-1 | 1 | 6 | 6-fold ↑ | Induces EC migration |
| 8 | PF4 | Platelet factor 4 | 0.79 | 3.94 | 4.98-fold ↑ | |
| 9 | ICAM1 | Intercellular adhesion molecule 1 | 11.5 | 23.85 | 2.07-fold ↑ |
CMpMSC conditioned medium of unstimulated pMSCs, pMSC placental mesenchymal stem cell, ↓ decrease, ↑ increase