Table 4.
pMSCs modulate expression of genes mediating endothelial cell (EC) permeability and leukocyte infiltration of ECs
| Number | Gene symbol | Gene full name | Glucose ΔΔ− 2 value | Glucose + CMpMSC ΔΔ− 2 value | Fold change, glucose vs glucose + CMpMSC (p < 0.05) | Biological activity |
|---|---|---|---|---|---|---|
| 1 | ALOX5 | Arachidonate 5-lipoxygenase | 103.45 | 17.62 | 53.05-fold ↓ | Induces EC permeability |
| 2 | ICAM1 | Intercellular adhesion molecule 1 | 11.5 | 23.85 | 2.07-fold ↑ | |
| 3 | NPR1 | Atrionatriuretic peptide receptor A | 1.16 | 3.79 | 3.26-fold ↑ | Inhibits EC permeability |
| 4 | CAV1 | Caveolin-1 | 5.87 | 3.16 | 1.85-fold ↓ | |
| 5 | ENG | Endoglin | 60.47 | 1.79 | 33.78-fold ↓ | Induces leukocyte infiltration |
| 6 | VCAM1 | Vascular cell adhesion molecule 1 | 64.03 | 1.79 | 35.77-fold ↓ | |
| 7 | SELL | Selectin L | 22.05 | 35.91 | 1.62-fold ↑ | |
| 8 | SELE | E-selectin | 22.05 | 35.91 | 1.62-fold ↑ |
CMpMSC conditioned medium of unstimulated pMSCs, pMSC placental mesenchymal stem cell, ↓ decrease, ↑ increase