Table 5.

pMSCs modulate expression of genes involved in endothelial cell (EC) survival, apoptosis, injury, fibrosis formation, and inflammation

Number	Gene symbol	Gene full name	Glucose ΔΔ−2 value	Glucose + ICpMSC ΔΔ− 2 value	Fold change, glucose vs. glucose + ICpMSC (p < 0.05)	Biological activity
1	PLAT	Plasminogen activator, tissue	4.52	247.12	54.67-fold ↑	Induces EC proliferation
2	PDGFRA	Platelet-derived growth factor receptor, alpha polypeptide	38	76	2-fold ↑
3	CAV1	Caveolin-1	6	2	3-fold ↓	Inhibits EC proliferation
4	COL18A1	Collagen, type XVIII, alpha 1	463	19	24-fold ↓
5	PROCR	Protein C receptor, endothelial	0.61	7.69	12.6-fold ↑	Induces EC survival
6	F2R	Protease-activated receptor-1	1.8	10.91	6.06-fold ↑
7	TGFB1	Transforming growth factor beta 1	0.96	37.26	138-fold ↑
8	BCL2L1	BCL2-like 1	1.4	140.43	100.3-fold ↑
9	MMP1	Matrix metallopeptidase 1	1.06	24	22.64-fold ↑
10	KDR	Vascular endothelial growth factor receptor 3 (VEGFR3)	0.62	50.83	81.92-fold ↑
11	SPHK1	Sphingosine kinase 1	1330.29	1,156,189.43	869.12-fold ↑
12	TNFSF10	TNF-related apoptosis-inducing ligand (TRAIL)	1.65	1788.25	1083-fold ↑
13	FASLG	Fas ligand	18,254.05	9.84	1855.08-fold ↓	Induces EC apoptosis
14	ENG	Endoglin	60.47	1.89	31.99-fold ↓	Induces EC injury
15	AGTR1	Angiotensin II receptor, type 1	2366.34	227.48	10.4-fold ↓
16	THBD	Thrombomodulin	131.78	10.19	12.93-fold ↓
17	IL3	Interleukin 3	47.75	0.59	80.93-fold ↓	Induces EC inflammation
18	ALOX5	Arachidonate 5-lipoxygenase	103.45	0.82	126.15-fold ↓
19	FLT1	Vascular endothelial growth factor receptor 1	7.14	1.96	3.64-fold ↓

ICpMSC intercellular direct contact experiment, pMSC placental mesenchymal stem cell, TNF tumour necrosis factor, ↓ decrease, ↑ increase