Table 6.
pMSCs modulate expression of genes mediating endothelial cell (EC) angiogenesis
| Number | Gene symbol | Gene full name | Glucose ΔΔ− 2 value | Glucose + ICpMSC ΔΔ− 2 value | Fold change, glucose vs glucose + ICpMSC (p < 0.05) | Biological activity |
|---|---|---|---|---|---|---|
| 1 | TIMP1 | TIMP metallopeptidase inhibitor 1 | 2.28 | 6.7 | 2.93-fold ↑ | Inhibits EC angiogenesis |
| 2 | CASP1 | Apoptosis-related cysteine peptidase | 0.01 | 8.97 | 897-fold ↑ | |
| 3 | PF4 | Platelet factor 4 | 0.79 | 3.54 | 4.48-fold ↑ | |
| 4 | AGT | Angiotensinogen | 3.3 | 0.54 | 6.1-fold ↓ | |
| 5 | COL18A1 | Collagen, type XVIII, alpha 1 | 463 | 19 | 24-fold ↓ | |
| 6 | F2R | Protease-activated receptor-1 | 1.8 | 10.91 | 6.06-fold ↑ | Induces EC angiogenesis |
| 7 | ICAM1 | Intercellular adhesion molecule 1 | 11.5 | 642.79 | 55.89-fold ↑ | |
| 8 | PGF | Placental growth factor | 3.21 | 178.53 | 55.56-fold ↑ | |
| 9 | CCL2 | Monocyte chemotactic protein-1 (MCP-1) | 17.72 | 44.51 | 2.52-fold ↑ | |
| 10 | PTGS2 | Cyclooxygenase (COX) | 1.9 | 3.84 | 2.02-fold ↑ | |
| 11 | SPHK1 | Sphingosine kinase 1 | 1330.29 | 1,156,189.43 | 869-fold ↑ | Induces EC migration |
| 12 | PF4 | Platelet factor 4 | 0.79 | 3.54 | 4.48-fold ↑ | |
| 13 | ICAM1 | Intercellular adhesion molecule 1 | 11.5 | 642.79 | 55.89-fold ↑ |
ICpMSC intercellular direct contact experiment, pMSC placental mesenchymal stem cell, ↓ decrease, ↑ increase