Table 7.
pMSCs modulate expression of genes mediating endothelial cell (EC) permeability and leukocyte infiltration of ECs
| Number | Gene symbol | Gene full name | Glucose ΔΔ−2 value | Glucose + ICpMSC ΔΔ− 2 value | Fold change, glucose compared with glucose + ICpMSC (p < 0.05) | Biological activity |
|---|---|---|---|---|---|---|
| 1 | ALOX5 | Arachidonate 5-lipoxygenase | 103.45 | 0.82 | 126.15-fold ↓ | Induces EC permeability |
| 2 | NPPB | Natriuretic peptide B | 4.12 | 0.04 | 103-fold ↓ | |
| 3 | IL1β | Interleukin 1 beta | 3.37 | 23.52 | 6.97-fold ↑ | |
| 4 | IL6 | Interleukin 6 | 0.43 | 32.23 | 74.95-fold ↑ | |
| 5 | ICAM1 | Intercellular adhesion molecule 1 | 11.5 | 642.79 | 55.89-fold ↑ | |
| 6 | CAV1 | Caveolin-1 | 5.87 | 2.5 | 2.34-fold ↓ | Inhibits EC permeability |
| 7 | NPR1 | Atrionatriuretic peptide receptor A | 1.16 | 12.58 | 10.84-fold ↑ | |
| 1 | ENG | Endoglin | 60.47 | 1.89 | 31.99-fold ↓ | Induces leukocyte infiltration |
| 2 | VCAM1 | Vascular cell adhesion molecule 1 | 64.03 | 1.19 | 53.8-fold ↓ | |
| 3 | SELL | Selectin L | 22.05 | 359.67 | 16.3-fold ↑ | |
| 4 | SELE | E-selectin | 22.05 | 359.67 | 16.31-fold ↑ |
ICPMSC intercellular direct contact experiment, pMSC placental mesenchymal stem cell, ↓ decrease, ↑ increase