Fig. 4.
The inhibition of LAT1 by JPH203 induces a cytostatic growth arrest in an ATC mouse model in vivo. a Slc7a5, Slc3a2, Slc1a5 and Slc38a2 transcription levels were quantified in BRAFV600E single-mutant (n = 5) and BRAFV600E/PIK3CAH1047R double-mutant (n = 11) mouse thyroid tumors 4 months after induction and compared to wild-type thyroids (n = 7) level. Transcription levels of each gene were normalized to Tuba1a and plotted as fold change relative to wild-type level. Statistical analysis was performed using a Kruskal-Wallis test with Dunn’s correction for multiple comparisons. b Outline of experimental procedure, as described in the text. c Slc7a5, transcription level was quantified in BRAFV600E/PIK3CAH1047R double-mutant mouse thyroid tumors after 10 days of treatments with PD-325901 at 5 mg/kg (n = 4) or GDC-0941 at 50 mg/kg (n = 5) or vehicle (n = 3)