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Minocycline prevents LPS-induced increase of RA-degradation in activated macrophages. LPS-stimulation significantly reduces retinoic acid (RA)-levels in THP1-cells. This effect can be reduced via minocycline: While pretreatment with 10 µM minocycline (MINO) results in a trend towards attenuating RA degradation, treatment with 100 µM minocycline results in a significant inhibition of LPS-induced RA-degradation. Results are presented as mean ± SEM, assessed in 3 independent experiments
