Fig. 8.

Additional reaction scheme for models in group 3 (kinetics-based models with regulation). Left: the reactions producing M are activated by M itself (product activation), in addition to the control of enzyme synthesis by M (R5). Right: depending on the incoming flux to M, two stable steady states are possible, as shown in the bifurcation diagram. Solid red curves denote stable steady states, while the dashed red curve denotes the unstable steady state. The circles mark the steady states at the beginning (blue) and at the end of the simulation (green)