Table 1.
Characteristics | Number of patients | Number of pCR (%) | Chi-squared test P value | Multivariate P value |
---|---|---|---|---|
Age | 0.564 | NS | ||
< 40 | 60 | 23 (38.3) | ||
40–59 | 194 | 66 (34.0) | ||
60+ | 49 | 14 (28.6) | ||
Menopausal status | 0.817 | NS | ||
Pre | 159 | 55 (34.6) | ||
Post | 144 | 48 (33.3) | ||
Tumor size at baseline | 0.026 | 0.030 | ||
T2 | 150 | 62 (41.3) | ||
T3 | 100 | 28 (28.0) | ||
T4 | 53 | 13 (24.5) | ||
Node status at baseline | 0.917 | NS | ||
- | 52 | 18 (34.6) | ||
+ | 251 | 85 (33.9) | ||
Histology at baseline | 0.263 | NS | ||
Invasive ductal carcinoma | 224 | 82 (36.6) | ||
Invasive (mixed) carcinoma | 62 | 17 (27.4) | ||
Others | 17 | 4 (23.5) | ||
Ki-67 expression at baseline | < 0.001 | 0.001 | ||
< 20% | 107 | 22 (20.6) | ||
≥ 20% | 196 | 81 (41.3) | ||
sMMP-9 at baseline (ng/ml) | 0.519 | NS* | ||
Low (< 505.5) | 101 | 34 (33.7) | ||
Intermediate (505.5–712.8) | 100 | 38 (38.0) | ||
High (> 712.8) | 102 | 31 (30.4) | ||
sMMP-9 at surgery (ng/ml) | 0.020 | 0.043* | ||
Low (< 423.2) | 100 | 42 (42.0) | ||
Intermediate (423.2–612.3) | 102 | 37 (36.3) | ||
High (> 612.3) | 101 | 24 (23.8) | ||
sMMP-9 decrease (ng/ml) | < 0.001 | 0.003* | ||
Low (< 28.3) | 100 | 24 (24.0) | ||
Intermediate (28.3–143.8) | 101 | 29 (28.7) | ||
High (> 143.8) | 102 | 50 (49.0) | ||
Clinical response | 0.172 | NS | ||
CR/PR | 102 | 40 (39.2) | ||
SD/PD | 201 | 63 (31.3) |
*sMMP-9 was studied in the multivariate analysis as linearly variable