Fig. 4.

The abundance of KARs in the synaptosome is decreased in Fmr1 KO mice. a, b, Total expression levels of GluK1 and GluK2/3 in the homogenates fraction of the insular cortex conducted from Fmr1 WT and Fmr1 KO mice were detected by Western blot. The expression levels of GluK1 and GluK2/3 in the homogenates were not altered between Fmr1 WT and Fmr1 KO mice (n = 3 mice for each group). c, d, Expression levels of GluK1 and GluK2/3 in the synaptosome of the insular cortex obtained from Fmr1 WT and Fmr1 KO mice were detected by western blot anaylsis. The expression levels of GluK1 and GluK2/3 in the homogenates was significantly reduced in Fmr1 KO mice compare to Fmr1 WT mice (n = 5 mice for each group). *P < 0.05