Table 3.
Correlations Between Plasma and Cerebrospinal Fluid (CSF) Soluble CD163 (sCD163) Levels During Chronic Human Immunodeficiency Virus Infection With Central Nervous System (CNS) Indices
| Source, Time, CNS Index | Rhoa | P a | CNS Outcome |
|---|---|---|---|
| Plasma | |||
| Before cART | |||
| Choline in frontal white matter, cellular infiltration | −0.346 | .049 | + |
| Acetylaspartate + N-acetylaspartylglutamic acid in posterior cingulate gyrus, neuronal health | −0.396 | .026 | − |
| Plasma neopterin, monocyte activation | 0.350 | .047 | − |
| After cART | |||
| Plasma neopterin, monocyte activation | 0.410 | .004 | − |
| CSF | |||
| Before cART | |||
| Myoinositol in frontal white matter, astrocytosis and gliosis | 0.379 | .019 | − |
| Choline in frontal white matter, cellular infiltration | 0.324 | .047 | − |
| N-acetylaspartate plus N-acetylaspartylglutamic acid in frontal gray matter, neuronal health | −0.402 | .011 | − |
| CSF neopterin, monocyte activation | 0.356 | .028 | − |
Abbreviations: cART, combination antiretroviral therapy; −, negative; +, positive.
aBy Spearman correlation analysis.