Figure 2.

Intravenous injection of varicella-zoster virus (VZV)-infected peripheral blood mononuclear cells (PBMCs) leads to latent infection of the guinea pig enteric nervous system (ENS). Four weeks after injection of VZV-infected PBMCs, the gut was removed and the longitudinal muscle and adherent myenteric plexus were dissected from the guinea pig small intestine, fixed, and prepared as whole mounts for immunocytochemistry. The immunoreactivity of VZV ORF63 (red) was detected in the cytoplasm of myenteric neurons identified with antibodies to the neuronal marker HuC/D. The bar = 36 µm.