Table 1.
Gene ontology analysis of differentially expressed genes associated with anaplastic thyroid cancer.
| Category | Term | Count | % | P value |
|---|---|---|---|---|
| Upregulated | ||||
| GOTERM_BP_DIRECT | GO: 0051301~cell division | 29 | 0.073774454 | 8.89E-14 |
| GOTERM_BP_DIRECT | GO: 0007067~mitotic nuclear division | 20 | 0.050878934 | 2.14E-09 |
| GOTERM_BP_DIRECT | GO: 0007155~cell adhesion | 24 | 0.06105472 | 1.32E-07 |
| GOTERM_BP_DIRECT | GO: 0007229~integrin-mediated signaling pathway | 12 | 0.03052736 | 1.36E-07 |
| GOTERM_BP_DIRECT | GO: 0000082~G1/S transition of mitotic cell cycle | 12 | 0.03052736 | 1.86E-07 |
| GOTERM_CC_DIRECT | GO: 0000776~kinetochore | 12 | 0.03052736 | 9.65E-09 |
| GOTERM_CC_DIRECT | GO: 0016020~membrane | 56 | 0.142461014 | 2.23E-06 |
| GOTERM_CC_DIRECT | GO: 0005615~extracellular space | 40 | 0.101757867 | 3.20E-06 |
| GOTERM_CC_DIRECT | GO: 0005925~focal adhesion | 18 | 0.04579104 | 1.99E-05 |
| GOTERM_CC_DIRECT | GO: 0000777~condensed chromosome kinetochore | 9 | 0.02289552 | 2.04E-05 |
| GOTERM_MF_DIRECT | GO: 0005515~protein binding | 160 | 0.407031469 | 2.37E-06 |
| GOTERM_MF_DIRECT | GO: 0005524~ATP binding | 42 | 0.106845761 | 2.64E-05 |
| GOTERM_MF_DIRECT | GO: 0005178~integrin binding | 9 | 0.02289552 | 1.19E-04 |
| GOTERM_MF_DIRECT | GO: 0005518~collagen binding | 7 | 0.017807627 | 1.95E-04 |
| GOTERM_MF_DIRECT | GO: 0004872~receptor activity | 12 | 0.03052736 | 2.65E-04 |
| Downregulated | ||||
| GOTERM_BP_DIRECT | GO: 0086005~ventricular cardiac muscle cell action potential | 4 | 0.011480265 | 2.30E-04 |
| GOTERM_BP_DIRECT | GO: 0014066~regulation of phosphatidylinositol 3-kinase signaling | 7 | 0.016072372 | 0.00136878 |
| GOTERM_BP_DIRECT | GO: 0030318~melanocyte differentiation | 5 | 0.009184212 | 0.001486948 |
| GOTERM_BP_DIRECT | GO: 0033539~fatty acid beta-oxidation using acyl-CoA dehydrogenase | 4 | 0.009184212 | 0.002576085 |
| GOTERM_BP_DIRECT | GO: 0009083~branched-chain amino acid catabolic process | 4 | 0.009184212 | 0.003024104 |
| GOTERM_CC_DIRECT | GO: 0070062~extracellular exosome | 77 | 0.176796088 | 9.63E-08 |
| GOTERM_CC_DIRECT | GO: 0016324~apical plasma membrane | 16 | 0.036736849 | 3.52E-05 |
| GOTERM_CC_DIRECT | GO: 0042383~sarcolemma | 8 | 0.018368425 | 2.86E-04 |
| GOTERM_CC_DIRECT | GO: 0016323~basolateral plasma membrane | 11 | 0.025256584 | 3.96E-04 |
| GOTERM_CC_DIRECT | GO: 0005856~cytoskeleton | 16 | 0.036736849 | 5.10E-04 |
| GOTERM_MF_DIRECT | GO: 0005516~calmodulin binding | 12 | 0.027552637 | 1.40E-04 |
| GOTERM_MF_DIRECT | GO: 0052890~oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | 4 | 0.009184212 | 0.001339754 |
| GOTERM_MF_DIRECT | GO: 0005200~structural constituent of cytoskeleton | 8 | 0.018368425 | 0.001372584 |
| GOTERM_MF_DIRECT | GO: 0003995~acyl-CoA dehydrogenase activity | 4 | 0.009184212 | 0.001630695 |
| GOTERM_MF_DIRECT | GO: 0044325~ion channel binding | 7 | 0.016072372 | 0.007246827 |