Table 3. IC50 of DRS-CA-1, DRS-DU-1, DP-1, and DP-2 against tested human cancer cells and human normal cell.
The cytotoxicity of dermaseptin B2 (DRSB2), dermaseptin PH (DRSPH), dermaseptin PD1 (DRSPD1) and dermaseptin PD2 (DRSPD2) obtained from published data were shown in the table for comparison.
| Cell lines | IC50 (µM) | |||||||
|---|---|---|---|---|---|---|---|---|
| DRS-CA-1 | DRS-DU-1 | DP-1 | DP-2 | DRSB2 | DRSPH | DRSPD1 | DRSPD2 | |
| HMEC-1 | >100 | 53.75 | >100 | >100 | NA | 4.85 | 36.35 | 27.28 |
| H157 | >100 | 8.43 | >100 | 3.21 | NA | 2.01 | NA | 6.43 |
| PC-3 | >100 | 21.6 | >100 | 6.75 | 2.17 | 11.8 | NA | 3.17 |
| MDA-MB-435s | >100 | >100 | >100 | >100 | >10 | 9.94 | NA | NA |
| U251MG | >100 | >100 | >100 | >100 | NA | 2.36 | 15.08 | 13.43 |
| MCF-7 | >100 | >100 | >100 | >100 | NA | 0.69 | NA | NA |
Notes.
NA, not tested.