Skip to main content
. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Semin Cell Dev Biol. 2018 Mar 22;83:29–35. doi: 10.1016/j.semcdb.2018.03.006

Figure 2. Multiple pathways to generate secretory late endosome or lysosomes.

Figure 2

Different unconventional protein secretion pathways may only differ in the initial substrate recruiting step. Cytosolic cargos can enter a secretory late endosomes (LE) via autophagosome (1) or through a Golgi independent vesicular trafficking route between the endoplasmic reticulum (ER) and LE (2), or in the case of MAPS (3), through direct translocation into the LE lumen. Invagination of LE membrane also generates intraluminal vesicles (green circles). The fusion of late endosomes with the plasma membrane (PM) results in the secretion of both exosome-bearing and exosome independent cargos.