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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Exp Neurol. 2018 Aug 1;309:91–106. doi: 10.1016/j.expneurol.2018.07.016

Figure 5. Expression of TLR-3-associated signaling genes in series of AD and nondemented brain samples.

Figure 5.

QPCR analyses of expression of interferon alpha (IFN-α) (A), interferon beta (IFN-β)(B) and interferon regulatory factor (IRF)-3 (C) in middle temporal gyrus of series of low plaque ND cases (n=18) and AD cases (n=24) of low plaque ND cases (n=18) and AD cases (n=24). There was significantly increased expression of IFN-β and IRF-3, but not IFN-α in the AD cases. Expression levels of IRF-3 correlated weakly with plaque score (D)(Spearman r = 0.381, p=0.012) and strongly with tangle scores (E) for these cases (r=0.413, p=0.0059).