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. 2018 Sep 23;22:228. doi: 10.1186/s13054-018-2154-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Inspiratory flow pattern, dynamic driving pressures during positive end-expiratory pressure (PEEP) titration, and the experimental scheme. a Inspiratory flow pattern of the small animal ventilator (SN-480-7, Shinano Seisakusho). b Changes in the dynamic driving pressures when decreasing PEEP from 10 to 0 cm H₂O at intervals of 2 cm H₂O. Data represent the means ± SD. c Schematic diagram of the experimental design. BGA, blood gas analysis; OLA, open lung approach; RM, recruitment maneuver