Table 2.
Cytokine concentrations (pg/mL) in phytohemagglutinin-stimulated (10 μg/mL) cocultures of MSC clones with PBMCs (mean ± SD).
| Concentration of cytokines (pg/mL) in PBMC : MSC cocultures | ||||||
|---|---|---|---|---|---|---|
| w/o MSC | 1.10 | 1.22 | 1.7 | 3.10 | 3.5 | |
| IL-1β | 2055.1 (151.5)a | 2344.6 (247.9)a | 2025.1 (498.3)a | 2809.0 (662.8)b | 2770.9 (712.0)b | 2136.7 (740.2)a |
| TNF-α | 416.8 (23.5)a | 32.4 (7.2)c | 42.5 (26.6)c | 208.6 (101.8)b | 79.9 (29.7)c | 14.1 (24.4)c |
| IL-10 | 819.4 (433.2)a | 352.2 (62.4)b | 531.8 (190.3)bc | 783.1 (312.2)ac | 455.0 (45.3)b | 531.4 (148.0)bc |
| IFN-γ | 2512.4 (1829.8)a | 359.9 (252.7)b | 270.3 (207.2)b | 3180.4 (1441.5)a | 2093.2 (1854.4)a | 186.1 (177.3)b |
| IL-4 | 1.9 (3.3) | — | — | — | — | — |
| IL-2 | 27.8 (31.6) | 18.9 (32.8) | 18.9 (32.8) | 22.5 (39.0) | — | — |
| IL-22 | 51.53 (77.31)ab | —a | 12.5 (21.7)ab | 40.7 (70.5)ab | 81.3 (71.0)b | —a |
| IL-13 | 998.0 (246.7)a | —b | 110.7 (96.7)bc | 123.2 (108.4)bc | 210.6 (325.7)c | —b |
| IL-17A | 549.3 (330.5)ab | 350.1 (90.4)a | 936.2 (508.1)cd | 906.6 (613.8)cd | 723.3 (307.0)bc | 1017.5 (403.0)d |
| IL-9 | 527.3 (126.4)a | —b | 20.2 (20.6)b | 119.3 (117.2)c | 45.7 (73.9)bc | 2.9 (2.6)b |
| IL-5 | 168.2 (120.8)a | 10.3 (17.9)b | 58.5 (50.8)bc | 63.9 (50.4)bc | 83.4 (110.2)c | 31.4 (54.4)bc |
| IL-12p70 | — | — | — | 37.4 (22.8) | — | — |
Groups (n = 3) containing the same letters are not statistically different for ANOVA (LSD), p < 0.05.