Table 3.
Effect of antidepressant or SSRI use on subsequent IBD activity based on univariate cox regression analysis.
| Glucocorticosteroid prescription or flare of disease activity | Escalation of Medical Therapy in Response to Uncontrolled Disease Activity | Hospitalisation due to Disease Activity | Intestinal resection | |||||
|---|---|---|---|---|---|---|---|---|
|
Hazard ratio (95% CI) |
P value |
Hazard ratio (95% CI) |
P value |
Hazard ratio (95% CI) |
P value |
Hazard ratio (95% CI) |
P value | |
|
Antidepressant use: all patients |
0.76 (0.47-1.22) |
0.25 | 0.59 (0.35-1.00) |
0.05 | 0.59 (0.231.50) |
0.26 | 1.15 (0.373.53) |
0.81 |
|
| ||||||||
| Antidepressant use: normal anxiety and depression scores at baseline | 0.77 (0.38-1.54) |
0.77 | 0.72 (0.36-1.44) |
0.35 | 1.01 (0.352.93) |
0.98 | 2.15 (0.558.50) |
0.27 |
|
| ||||||||
| Antidepressant use: abnormal anxiety or depression scores at baseline | 0.63 (0.32-1.23) |
0.17 | 0.47 (0.21-1.05) |
0.07 | 0.20 (0.031.57) |
0.13 | 0.37 (0.053.04) |
0.36 |
|
| ||||||||
| SSRI use: all patients | 0.74 (0.41-1.31) |
0.30 | 0.47 (0.24-0.93) |
0.03 | 0.35 (0.081.46) |
0.15 | 0.86 (0.193.85) |
0.84 |
|
| ||||||||
| SSRI use: normal anxiety and depression scores at baseline | 0.76 (0.31-1.91) |
0.56 | 0.49 (0.18-1.37) |
0.18 | 0.87 (0.203.75) |
0.86 | 2.39 (0.4712.2) |
0.29 |
|
| ||||||||
| SSRI use: abnormal anxiety or depression scores at baseline | 0.58 (0.27-1.26) |
0.17 | 0.43 (0.17-1.11) |
0.08 | 0.03 (0.0010.1) |
0.24 | 0.03 (0.0073.9) |
0.39 |