Table 2.
Cut-off values, odds ratios, and AUCs for the diagnosis of LOAD calculated for each single serum parameter.
| Cut-off∗ | OR (p) | AUC | |
|---|---|---|---|
| AOPP | 70 μmol/L | 1.66 (p = 0.075) | 0.563 |
| Hydroperoxides | 330 CU | 1.72 (p = 0.035) | 0.566 |
| RAP | 190 FRAP units | 3.18 (p < 0.001) | 0.640 |
| Thiols | 190 μmol/L | 3.16 (p < 0.001) | 0.640 |
| Uric acid | 279 μmol/L | 4.14 (p < 0.001) | 0.653 |
| Homocysteine | 14 μmol/L | 2.17 (p = 0.013) | 0.595 |
| Paraoxonase | 90 U/L | 1.22 (p = 0.375) | 0.525 |
| Arylesterase | 94 kU/L | 2.89 (p < 0.001) | 0.629 |
| Total FeOx | 510 U/L | 1.56 (p = 0.097) | 0.554 |
∗Cut-off points corresponding to the best compromise between specificity and sensitivity. Abbreviations: OR, odds ratio; LOAD: late onset Alzheimer's disease; CVD: cardiovascular disease; AOPP, advanced oxidation protein products; total FeOx, total ferroxidase; RAP, residual antioxidant power; CU, Carr units (1 CU = 0.023 mmol/L of H2O2); FRAP units, ferric reduction antioxidant power (1 FRAP unit = 100 μmol/L of Fe3+ reduced to Fe2+).