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Inhibitory effects of the novel prodrugs in comparison with the respective free TKI on RTK signaling. A) Sunitinib-sensitive A431 and B) erlotinib-hypersensitive PC-9 cells were grown in medium with fetal calf serum (FCS) and treated with the indicated drug for 4 h. They were then harvested and lysed, and the impact on ERK phosphorylation as a read out for RTK signaling was analyzed by western blotting. Sun = sunitinib, Erlo = erlotinib, N = normoxia, H = hypoxia.
