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. Author manuscript; available in PMC: 2018 Sep 23.
Published in final edited form as: ChemMedChem. 2016 Oct 5;11(21):2410–2421. doi: 10.1002/cmdc.201600417

Figure 7.

Figure 7

3D structures of A) erlotinib and compound 2c, and B) erlotinib, 2a and 2b in complex with EGFR. The structure of the EGFR–erlotinib complex was obtained from PDB ID: 1M17. The protein is depicted in ribbon representation colored in green and was rendered as a surface representation. Compounds are shown in capped stick representation and colored as follows: A) erlotinib in gold, 2c in sky blue; B) erlotinib in gold, 2a in sky blue and 2b in magenta. The pictures were generated using Chimera.