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. Author manuscript; available in PMC: 2018 Sep 23.
Published in final edited form as: ChemMedChem. 2016 Oct 5;11(21):2410–2421. doi: 10.1002/cmdc.201600417

Scheme 1.

Scheme 1

Postulated schematic pathway of TKI release for A) two-part compounds upon trigger reduction, and B) three-part compounds upon trigger reduction and linker decomposition.