Table 3.
IC50 values of sunitinib, 1a, and 1b against the indicated cell lines under normoxia vs. hypoxia after 72 h of treatment.
| Cell line | Sunitinib | 1a | 1b | ||||||
|---|---|---|---|---|---|---|---|---|---|
| IC50 [μm][a] | fold diff. | IC50 [μm][a] | fold diff. | IC50 [μm][a] | fold diff. | ||||
| N | H | N | H | N | H | ||||
| A431 | 5.9 ± 1.4 | 4.2 ± 0.6 | 1.4 | 6.8 ± 0.3 | 4.4 ± 0.1 | 1.5 | 6.7 ± 0.5 | 4.5 ± 0.5 | 1.5 |
| Caki-1 | 6.8 ± 0.2 | 7.6 ± 1.4 | 0.9 | 6.6 ± 0.4 | 6.6 ± 0.5 | 1.0 | 5.5 ± 1.4 | 5.6 ± 1.2 | 1.0 |
| HCC827 | 5.2 ± 0.5 | 3.4 ± 0.1 | 1.4 | 5.5 ± 1.0 | 3.5 ± 0.3 | 1.6 | 5.5 ± 1.7 | 3.9 ± 1.2 | 1.4 |
| HCT116 | 2.2 ± 1.5 | 2.0 ± 1.2 | 1.1 | 2.1 ± 1.7 | 2.2 ± 1.3 | 1.0 | 1.9 ± 1.3 | 2.1 ± 1.3 | 0.9 |
| H1703 | 0.5 ± 0.0 | 0.5 ± 0.0 | 1.0 | 0.5 ± 0.0 | 0.5 ± 0.0 | 1.0 | 0.5 ± 0.0 | 0.5 ± 0.0 | 1.0 |
[a]
Values are the mean ± SD of n = 3 experiments performed in triplicate; N: normoxia, H: hypoxia.