Table 4.
IC50 values of 2a, 2b, and 2c against the indicated cell lines under normoxia vs. hypoxia after 72 h of treatment.
| Cell line | 2a | 2b | 2c | ||||||
|---|---|---|---|---|---|---|---|---|---|
| IC50 [μm][a] | fold diff. | IC50 [μm][a] | fold diff. | IC50 [μm][a] | fold diff. | ||||
| N | H | N | H | N | H | ||||
| A431 | 15.0 ± 3.5 | 16.7 ± 2.8 | 1.1 | > 25 | > 25 | 1.0 | 3.8 ± 2.5 | 2.5 ± 1.4 | 1.5 |
| HCC827 | 2.7 ± 1.4 | 1.9 ± 0.9 | 1.4 | 2.7 ± 0.9 | 1.8 ± 0.3 | 1.5 | 2.6 ± 1.0 | 2.1 ± 1.1 | 1.2 |
| PC-9 | 7.5 ± 1.0 | 7.0 ± 0.9 | 1.1 | 6.8 ± 2.1 | 3.2 ± 0.1 | 2.1 | 6.0 ± 2.8 | 3.0 ± 0.8 | 2.0 |
| Calu3 | 15.5 ± 1.3 | 15.5 ± 3.4 | 1.0 | > 25 | 14.9 | > 1.7 | 5.8 ± 3.7 | 5.0 ± 3.8 | 1.2 |
| SW480 | > 25 | > 25 | 1.0 | > 25 | > 25 | 1.0 | 2.4 ± 1.5 | 1.8 ± 1.1 | 1.3 |
| MCF-7 | 9.0 ± 1.0 | 12.4 ± 2.8 | 0.8 | > 25 | > 25 | 1.0 | 0.6 ± 0.0 | 0.7 ± 0.1 | 0.9 |
[a]
Values are the mean ± SD of n = 3 experiments performed in triplicate; N: normoxia, H: hypoxia.