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. Author manuscript; available in PMC: 2018 Sep 23.
Published in final edited form as: ChemMedChem. 2016 Oct 5;11(21):2410–2421. doi: 10.1002/cmdc.201600417

Table 5.

IC50 values of erlotinib and TH-302 against the indicated cell lines under normoxia vs. hypoxia after 72 h of treatment.

Cell line Erlotinib TH-302
IC50 [μm][a] fold diff. IC50 [μm][a] fold diff.
N H N H
A431      7.6 ± 1.7      9.9 ± 2.9 0.8    22.4 ± 2.6 5.4 ± 3.4   4.1
HCC827      0.3 ± 0.2      0.3 ± 0.2 1.0 > 10 7.4 ± 0.0   > 1.4
PC-9      1.4 ± 0.8      1.3 ± 0.9 1.1    10.0 ± 0.0 5.9 ± 4.1   1.7
Calu3      2.0 ± 0.5      1.3 ± 0.4 1.5    17.5 ± 7.5 6.3 ± 3.7   2.8
SW480 > 25 > 25 1.0    20.6 ± 5.9 8.3 ± 2.9   2.5
MCF-7 > 25 > 25 1.0    22.5 ± 2.5 2.2 ± 0.4 10.2
[a]

Values are the mean ± SD of n = 3 experiments performed in triplicate; N: normoxia, H: hypoxia.