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. 2018 Sep 20;131(18):jcs216226. doi: 10.1242/jcs.216226

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Rab4A depletion increases the number of vacuolar endosomes and inhibits melanosome maturation in melanocytes. (A–C) Electron microscopy analysis of control and Rab4A-knockdown melanocytes. M, mitochondria; MVB, multi-vesicular bodies; MC, melanosome cluster; N, nucleus; VE, vacuolar endosomes; II/III/IV, stages of melanosomes. Scale bars: 2 µm. (B) Percentage of each melanosome stage (mean±s.e.m., quantified as Materials and Methods) for both conditions. Significant changes in the values are highlighted in red box. (C) Melanosomes or vacuoles per µm² of cytosol, or percentage of melanosomes in a cluster (mean±s.e.m.) for both the conditions.