TABLE 1.
Missense mutation SNPs linked to cancer phenotypes (p-values of at least one inheritance model < 0.05). Data for polymerase genes for breast and prostate cancers are from Swett et al15.
| breast | prostate | lung | pancreatic | CLL | DLBCL | FL | MZL | |
|---|---|---|---|---|---|---|---|---|
| ABH7 | rs7540 | |||||||
| MSH3 | rs184967 rs26279 |
|||||||
| POLE | rs4883543 rs4883544 |
|||||||
| POLA2 | rs487989 | |||||||
| POLD1 | rs1726801 | |||||||
| POLG | rs2307441 | rs3087374 | ||||||
| POLG2 | rs1427463 | |||||||
| POLI | rs8305 | |||||||
| POLL | rs3730463 | rs3730476 | rs3730463 rs3730476 |
rs3730476 | ||||
| POLN | rs9328764 rs10011549 rs1001878 |
rs11937432 rs2353552 |
||||||
| POLQ | rs3218651 | rs3218651 | rs3218651 | rs3218642 | ||||
| REV3L | rs462779 | |||||||
| TET1 | rs12221107 | rs12221107 rs16925541 |
rs3998860 | rs3998860 | ||||
| APO2 | rs2076472 | rs2076472 | ||||||
| APO3G | rs8177832 | |||||||
| APO3H | rs139298 | rs139297 | rs139297 | |||||
| APO4 | rs1174657 rs1174658 |
rs16861394 | ||||||
| MBD4 | rs140693 | rs2307293 | ||||||
| MUTYH | rs3219484 | rs3219484 | rs3219484 | |||||
| NEIL2 | rs8191613 rs8191664 |
|||||||
| NEIL3 | rs13112390 rs13112358 |
rs13112358 | rs1876268 | rs1876268 | rs13112358 rs13112390 rs1876268 |
|||
| APEX1 | rs1130409 | |||||||
| APEX2 | rs2301416 | |||||||
| PARP1 | rs1136410 | rs1136410 | ||||||
| PARP2 | rs3093921 | rs3093921 |