Skip to main content
. 2018 Sep 6;175(20):3928–3946. doi: 10.1111/bph.14465

Figure 7.

Figure 7

Rosiglitazone‐induced HO‐1 expression via NOX/ROS‐dependent c‐Src/Pyk2/Akt pathway. HPAEpiCs were (A) transfected with p47phox or NOX2 siRNA, and pretreated with APO or DPI, (B) c‐Srci II, (C) PF431396 or (D) Akti VIII for 1 h, and then incubated with vehicle or rosiglitazone (30 μM) for the indicated time intervals. Western blot was performed by using an anti‐phospho‐c‐Src, anti‐c‐Src, anti‐phospho‐Pyk2, anti‐Pyk2, anti‐phospho‐Akt or anti‐Akt antibody. Data are expressed as mean ± SEM, from five independent experiments (n = 5). # P < 0.05, significantly different from rosiglitazone alone.