Table 3.
Antifungal activity of sulfadiazine derivatives 2.
| Code | R | MIC (µM) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CA | CT | CK | CG | TA | AF | LC | TI | ||||||||||
| 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | 72 h | 120 h | ||
| 2a | H | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | 125 | 125 |
| 2b | 5-F | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 |
| 2c [4] | 5-Cl | 125 | 125 | >500 | >500 | >500 | >500 | 125 | 125 | 62.5 | 125 | >500 | >500 | >500 | >500 | >500 | >500 |
| 2d | 5-Br | 125 | 125 | 250 | 250 | 250 | 250 | 62.5 | 62.5 | 62.5 | 62.5 | 250 | 250 | >500 | >500 | 62.5 | 62.5 |
| 2e | 5-I | 62.5 | 125 | 125 | 125 | 62.5 | 125 | 62.5 | 62.5 | 125 | 125 | 250 | 250 | >500 | >500 | 31.25 | 31.25 |
| 2f | 5-NO2 | 500 | 500 | >500 | >500 | >500 | >500 | 250 | 250 | >500 | >500 | >500 | >500 | 500 | 500 | 62.5 | 62.5 |
| 2g | 5-CH3 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 | >500 |
| 2h | 5-CH3O | 500 | 500 | 500 | 500 | >500 | >500 | 500 | 500 | 500 | 500 | >500 | >500 | >500 | >500 | 62.5 | 62.5 |
| 2i | 5-OH | 15.62 | 15.62 | 15.62 | 15.62 | 31.25 | 31.25 | 15.62 | 15.62 | 15.62 | 15.62 | 125 | 125 | 500 | 500 | 1.95 | 1.95 |
| 2j | 5-tert-Bu | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | 62.5 | 62.5 |
| 2k | 6-Cl | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 | >250 |
| 2l | 3-Cl | 62.5 | 62.5 | 125 | 125 | 250 | 250 | 125 | 125 | 125 | 125 | 250 | 250 | >500 | >500 | 31.25 | 31.25 |
| 2m | 3,5-Cl2 | 62.5 | 62.5 | 125 | 125 | 62.5 | 62.5 | 31.25 | 31.25 | 62.5 | 62.5 | 250 | 250 | 500 | 500 | 125 | 125 |
| 2n | 3-Br-5-Cl | 31.25 | 31.25 | 62.5 | 62.5 | 62.5 | 62.5 | 31.25 | 31.25 | 62.5 | 62.5 | 250 | 250 | 500 | 500 | 62.5 | 62.5 |
| 2o | 3-I-5-Cl | 7.81 | 7.81 | 7.81 | 7.81 | 7.81 | 7.81 | 7.81 | 7.81 | 7.81 | 7.81 | 62.5 | 62.5 | 250 | 250 | 1.95 | 1.95 |
| 2p | 3,5-I2 | 3.9 | 3.9 | 7.81 | 7.81 | 7.81 | 7.81 | 3.9 | 3.9 | 3.9 | 3.9 | 62.5 | 62.5 | 62.5 | 62.5 | 15.62 | 15.62 |
| 2q | - | 250 | 250 | 250 | 250 | 250 | 250 | 250 | 250 | 500 | 500 | 500 | 500 | >500 | >500 | 250 | 250 |
| FLU | - | 0.24 | 0.24 | >500 | >500 | 125 | 250 | 31.25 | 500 | 250 | 500 | >500 | >500 | >500 | >500 | 7.81 | 125 |
FLU = fluconazole; SDZ = sulfadiazine 1. CA: Candida albicans ATCC 44859; CT: Candida tropicalis; CK: Candida krusei E28; CG: Candida glabrata 20/I; TA: Trichosporon asahii 1188; AF: Aspergillus fumigatus 231; LC: Lichtheimia corymbifera 272; TI: Trichophyton interdigitale 445. One or two of the best MIC value(s) for each strain are shown in bold.