Table 1.
Plasma biochemical markers analyzed.
| Variable | Control | Melatonin Treatment (Months) | ||
|---|---|---|---|---|
| 0 | 3 | 6 | ||
| CPK | 114.3 ± 45.2 | 146.3 ± 73.2 | 155.5 ± 70.5 | 83.7 ± 40.8 ***,### |
| LDH | 248.4 ± 44.6 | 407.2 ± 79.2 ** | 380.4 ± 46.2 * | 339.1 ± 17.5 *,# |
| AST | 23.4 ± 5.1 | 29.7 ± 5.3 * | 25.6 ± 5.3 | 23.8 ± 6.0 # |
| ALT | 24.4 ± 3.2 | 17.7 ± 0.6 * | 14.8 ± 3.0 ** | 12.2 ± 2.1 *** |
| γGT | 25.5 ± 2.5 | 11.9 ± 5.5 ** | 13.2 ± 2.5 ** | 16.3 ± 8.9 **,# |
| Aldolase | 6.7 ± 2.1 | 4.7 ± 1.6 | 3.5 ± 0.7 ** | 2.4 ± 0.2 ***,# |
| Alkaline phosphatase | <350 | 188.5 ± 101.2 | 174.2 ± 75.0 | 153.2 ± 75.8 |
| Myoglobin | 50.6 ± 10.4 | 23.7 ± 2.5 *** | 22.9 ± 3.1 *** | 24.7 ± 2.4 *** |
| Calcium | 9.7 ± 0.5 | 9.3 ± 0.1 | 9.5 ± 0.3 | 9.4 ± 0.3 |
| Phosphate | 3.8 ± 0.8 | 4.3 ± 0.1 | 4.7 ± 0.1 | 4.4 ± 0.1 |
Data are expressed as the means ± SEM. Enzyme activities are expressed in U/L; myoglobin concentration in ng/L, and calcium and phosphate levels in mg/dL. * p < 0.05, ** p < 0.01, and *** p < 0.001 vs. control; # p < 0.05, and ### p < 0.001 vs. 0.