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Raw 264.7 cells were incubated for 24 h with lipopolysaccharide (LPS; 10 μg mL−1) in the absence or presence of various Phosphodiesterase (PDE) inhibitors (10 μM), and the production of nitrite was evaluated by the Griess reaction. Cells were pretreated with inhibitors for 1 h before lipopolysaccharide (LPS) stimulation. Values represent the mean ± SD from two independent experiments. *: p < 0.05; **: p < 0.01 versus LPS-treated cells.
