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. 2018 Aug 17;9(9):1439–1456. doi: 10.1039/c8md00342d

Table 1. BLIs currently in the clinical development stage.

Name/code Chemical class Clinical development phase
Nacubactam Diazabicyclooctane Phase I in combination with meropenem
Zidebactam Diazabicyclooctane Phase I in combination with cefepime
ETX2514 Diazabicyclooctane Phase II in combination with sulbactam
Relebactam Diazabicyclooctane Phase III in combination with imipenem/cilastatin
Avibactam Diazabicyclooctane Approved in combination with ceftazidime
Phase II in combination with ceftaroline fosamil
Phase I in combination with aztreonam
Vaborbactam Cyclic boronate Approved in combination with meropenem
Phase I in combination with biapenem
AAI101 Penam sulfone Phase II in combination with cefepime