Table 4.
Nutrient receptors expressed by enteroendocrine ghrelin, CCK, GLP-1, and PYY cells
| Nutrient Receptor | Ghrelin | CCK | GLP-1 | PYY |
|---|---|---|---|---|
| CASR (CaR) | X | X | X | X |
| CD36 | X | |||
| FFAR1 (GPR40) | X | |||
| FFAR2 (GPR43) | X | X | ||
| FFAR3 (GPR41) | X | |||
| FFAR4 (GPR120) | X | X | X | |
| GNAT3 (gustducin) | X | X | ||
| GPR119 | X | |||
| HCAR1 (GPR81) | X | |||
| LPAR5 (GPR93) | X | |||
| SLC2A1 (GLUT1) | X | |||
| SLC2A2 (GLUT2) | X | |||
| SLC2A5 (GLUT5) | X | |||
| SLC5A1 (SGLT1) | X | |||
| SLC15A1 (PEPT1) | X | X | ||
| TAS1R1/TAS1R3 (T1R1/T1R3) | X | X | ||
| TAS1R2/TAS1R3 (T1R2/T1R3) | X | X | ||
| TAS1R3 (T1R3) | X |
The table is based on the evidence of receptor expression in mice, rats, or humans discussed in the text. Former names of the receptors are given in parentheses. CaR, calcium receptor; CASR, calcium-sensing receptor; CD36, thrombospondin receptor; FFAR, free fatty acid receptor; GLUT, glucose transporter; GNAT3, guanine nucleotide-binding protein, alpha transducing 3; GPR, G protein-coupled receptor; HCAR1, hydroxycarboxylic acid receptor 1; LPAR5, lysophosphatidic acid receptor 5; PEPT1 and SLC15A1, solute carrier family 15 (oligopeptide transporter), member 1; TAS1R1 and T1R1, taste receptor, member 1; TAS1R2 and T1R2, taste receptor, member 2; TAS1R3 and T1R3, taste receptor, member 3 (T1R1/T1R3). Note that abbreviations are for the human genes, although many of the receptors indicated have been identified on the respective enteroendocrine cells so far only in mice or rats.