Table 2.

The log K_app(o/w) (pH 7.4 and pH 1.2) values of naproxen and its conjugates at 37 °C.

Compound	pH 7.4	pH 1.2
NAP	0.11 ± 0.01	2.8 ± 0.7
G0-deg-NAP	−1.07 ± 0.09	−1.17 ± 0.1
L-G0-deg-NAP	−0.19 ± 0.07	−0.18 ± 0.05
G3-(deg-NAP)5	−0.36 ± 0.12	−0.35 ± 0.19
G3-(deg-NAP)10	−0.40 ± 0.13	−0.37 ± 0.17
L6G3-(deg-NAP)5	−0.40 ± 0.09	−0.32 ± 0.11
L12G3-(deg-NAP)5	−0.18 ± 0.04	−0.17 ± 0.09