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The solubility (pH 1.2) naproxen and its conjugates at 37 °C.
| Compound | Solubility mg/mL | Solubility Eq. con. NAP * (mM) |
|---|---|---|
| NAP | 0.06 | 0.26 |
| G0-deg-NAP | >50 | >58 |
| L-G0-deg-NAP | 35 ± 12 | 32 ± 11 |
| G3-(deg-NAP)5 | >50 | >28 |
| G3-(deg-NAP)10 | >50 | >48.2 |
| L6G3-(deg-NAP)5 | 29 ± 17 | 14 ± 8.2 |
| L12G3-(deg-NAP)5 | 18 ± 12 | 8 ± 5.7 |
* Equivalent concentration of naproxen (mM).
