FIGURE 14.

MGE and CGE-dependent expression of synaptic AMPAR-preferring glutamate receptors. A and B, top panels: interneurons that were targeted for recording using hippocampal slices derived from Nkx2–1-cre:RCE GFP and Htr3a-GFP reporter mouse lines, respectively (Scale bars, 100 μm). Middle panels: representative current-voltage relationships of Schaffer collateral-evoked AMPAR-mediated EPSCs in MGE- vs. CGE-derived CA1 interneurons. MGE-derived interneurons typically possess GluA2-lacking CP-AMPARs that possess strong inward rectification (left bottom panels). CGE-derived interneurons typically expressed GluA2-containing CI-AMPARs which possess near linear rectification properties. Individual dots in bottom panels represent data from a single recording; numbers in parentheses represent the number of cells recorded. [Data from Matta et al. (763).]